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Ingredients

Gamma-Aminobutyric Acid

Gaba

Gamma aminobutyric acid (GABA) is a naturally occurring amino acid that works as a neurotransmitter in your brain. Neurotransmitters function as chemical messengers. GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system.*

When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. This can help with feelings of anxiety, stress, and fear. It may also help to prevent seizures.*

As a result of these properties, GABA has also become a popular supplement in recent years. This is partly because it isn’t available from many food sources. The only foods that contain GABA are fermented ones, such as kimchi, miso, and tempeh.*

GABA’s natural calming effect on the brain has led to countless claims about the use of GABA supplements to reduce stress. Too much stress is linked to poor sleep, a weaker immune system, and a higher risk of depression, among other things.*

S-Adenosyl Methionine

SAM-e

A compound that's made naturally in the body and plays an important role in normal bodily function. A synthesized form of SAM-e is considered a supplement in the U.S., but SAM-e has been sold as a prescription drug in parts of Europe for decades. Its scientific name is S-adenosylmethionine. SAM-e is also known as ademetionine and SAMe.*

SAM-e appears to be an effective treatment for depression: Five of seven sources agree, and the two others say it's promising. SAM-e can be used alone or in conjunction with other antidepressants.*

Since its side effects are less than those of many antidepressants, SAM-e is better tolerated by many people: It works more rapidly and does not cause weight gain, sexual dysfunction, sedation, or cognitive interference. One leading researcher (Brown et al.) calls SAM-e a "first line CAM treatment" for mild, moderate, or even severe depression.*

S-Adenosyl methionine is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver.*

Withania Somnifera

Ashwagandha

known commonly as ashwagandha, Indian ginseng, poison gooseberry, or winter cherry, is a plant in the Solanaceae or nightshade family. Several other species in the genus Withania are morphologically similar.*

Ashwagandha is commonly used for stress. It is also used as an "adaptogen" for many other conditions, but there is no good scientific evidence to support these other uses.*

Ashwagandha is one of the most important herbs in Ayurveda, a form of alternative medicine based on Indian principles of natural healing. It has been used for over 3,000 years to relieve stress, increase energy levels, and improve concentration.*

A number of studies suggest that it has anxiolytic (anti-anxiety) effects; studies are mostly supportive of a notable effect of ashwagandha for this purpose, and it seems to reduce cortisol levels. However, more research is needed before we can have a great deal of confidence in it or know the optimal dose. Ashwagandha may also be able to reduce insomnia, fatigue, and the symptoms of depression, but it hasn't been well-researched for these purposes.*

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